Article
Specific GABAA circuits for visual cortical plasticity.
Science (New York, N.Y.) - 12 Mar 2004
Fagiolini Michela, Fritschy Jean-Marc, Löw Karin, Möhler Hanns, Rudolph Uwe, Hensch Takao K
Abstract excerpt
Weak inhibition within visual cortex early in life prevents experience-dependent plasticity. Loss of responsiveness to an eye deprived of vision can be initiated prematurely by enhancing gamma-aminobutyric acid (GABA)-mediated transmission with benzodiazepines. Here, we use a mouse "knockin" muta...
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