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Article

Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft.

Journal of virology - 1 Apr 2004

Gao Lu, Aizaki Hideki, He Jian-Wen, Lai Michael M C

Abstract excerpt

The lipid raft membrane has been shown to be the site of hepatitis C virus (HCV) RNA replication. The mechanism of formation of the replication complex is not clear. We show here that the formation of the HCV RNA replication complex on lipid raft (detergent-resistant membranes) requires interactions among the HCV nonstructural (NS) proteins and may be initiated by the precursor of NS4B, which has the intrinsic...

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Identifiers

PMID: 15016871
DOI: 10.1128/jvi.78.7.3480-3488.2004
PMCID: PMC371042

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