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Article

Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein.

Journal of virology - 1 Jun 2005

Gosert Rainer, Jendrsczok Wiebke, Berke Jan Martin, Brass Volker, Blum Hubert E, Moradpour Darius

Abstract excerpt

Protein-protein interactions involved in formation of the membrane-associated hepatitis C virus (HCV) replication complex are poorly understood. Here, we investigated nonstructural proteins with deletions in their membrane anchor domains when expressed in the context of the entire HCV polyprotein. Interactions among cytosolic domains of HCV nonstructural proteins were found not to be sufficiently strong to rescue...

Topics

Cell Line, Tumor
Cell Membrane
Gene Deletion
Hepacivirus
Humans
Membrane Microdomains
Mutation
Polyproteins
Subcellular Fractions
Viral Nonstructural Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15919947
DOI: 10.1128/JVI.79.12.7911-7917.2005
PMCID: PMC1143632

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