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Article

Allostery and coupled sequence variation in nuclear hormone receptors.

Cell - 6 Feb 2004

Kuriyan John

Abstract excerpt

The analysis of correlated sequence variation in evolutionarily related proteins is beginning to provide useful information regarding allosteric coupling between different functional sites. Such an analysis has been carried out for the nuclear hormone receptors, and the conclusions tested by making mutations that switch the allosteric response to ligands of RXR heterodimers.

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Share to Allosteric Regulation
Share to Amino Acid Sequence
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Binding

Share to Protein Structure, Tertiary

Share to Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 15016369
DOI: 10.1016/s0092-8674(04)00125-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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