Effect of reciprocal complementation of two defective human immunodeficiency virus type 1 (HIV-1) molecular clones on HIV-1 cell tropism and virulence.

doi:10.1128/JVI.66.9.5553-5560.1992

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Article

Effect of reciprocal complementation of two defective human immunodeficiency virus type 1 (HIV-1) molecular clones on HIV-1 cell tropism and virulence.

Journal of virology - 1 Sept 1992

Lori F, Hall L, Lusso P, Popovic M, Markham P, Franchini G, Reitz M S

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication. It is unclear to what extent defective viruses play a role in the process of HIV-1 infection or...

Topics

Base Sequence
Cells, Cultured
Cloning, Molecular
Defective Viruses
Genetic Complementation Test
Genetic Variation
Genome, Viral
HIV-1
Humans
Leukocytes, Mononuclear
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Specificity

Polymerase Chain Reaction

Recombination, Genetic

Transfection

Virulence

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1501290
DOI: 10.1128/JVI.66.9.5553-5560.1992
PMCID: PMC289114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1501290-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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