Article
Superinfection of a defective human immunodeficiency virus type 1 provirus-carrying T cell clone with vif or vpu mutants gives cytopathic virus particles by homologous recombination.
AIDS research and human retroviruses - 1 Jan 1995
Kishi M, Tokunaga K, Zheng Y H, Bahmani M K, Kakinuma M, Nonoyama M, Lai P K, Ikuta K
Abstract excerpt
The partially CD4-expressing T cell clone, Vpr-1, which carries a latent vpr-defective HIV-1 genome and expresses HIV-1 Nef protein only, was permissive to superinfection by HIV-1. Superinfection of Vpr-1 with vif- or vpu-defective mutants, which were noncytopathic, reactivated the vpr-defective virus and led to homologous recombination and cytopathogenesis. The data provide an experimental model for homologous...
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