Article
Population differences in DNA sequence variation and linkage disequilibrium at the PON1 gene.
Annals of human genetics - 1 Mar 2004
Koda Y, Tachida H, Soejima M, Takenaka O, Kimura H
Abstract excerpt
Polymorphisms of the promoter region (-108C/T) and the coding region (192Q/R) of the paraoxonase 1 gene (PON1) showed differences in association with cardiovascular disease risk in various populations. To characterize the genetic variation underlying these important polymorphisms, we examined DNA sequence variation both in a 1.3-kb promoter region 16.5 kb from codon 192, and in a 1.7-kb region centered on the...
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