Article
HLA-DQA1*03:02/DQB1*03:03:02 is strongly associated with susceptibility to childhood-onset ocular myasthenia gravis in Southern Han Chinese.
Journal of neuroimmunology - 15 Jun 2012
Zhu Wen-Hua, Lu Jia-Hong, Lin Jie, Xi Jian-Ying, Lu Jun, Luo Su-Shan, Qiao Kai, Xiao Bao-Guo, Lu Chuan-Zhen, Zhao Chong-Bo
Abstract excerpt
OBJECTIVE: Our aim was to investigate the correlation between onset age, clinical features and HLA-DQA1/DQB1 genetic variability in myasthenia gravis (MG) patients in Southern Han Chinese. METHODS: 205 MG patients and 100 controls were genotyped for HLA-DQA1 and -DQB1 using sequence-based typing (SBT) and analyzed for haplotype frequencies. Anti-acetylcholine receptor (AChR) autoantibodies were measured in all,...
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