Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methods to Increase the Percentage of Free Fetal DNA Recovered From the Maternal Circulation

2 Mar 2004

Abstract excerpt

CONTEXT: Noninvasive prenatal diagnostic tests using free fetal DNA provide an alternative to invasive tests and their attendant risks; however, free fetal DNA exists in the maternal circulation at low percentages, which has hindered development of noninvasive tests. OBJECTIVE: To test the hypothesis that using formaldehyde to reduce cell lysis could increase the relative percentage of free fetal DNA in samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fetal and Pediatric Neurological Disorders
Share to Pregnancy and preeclampsia studies
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14996781
DOI: 10.1001/jama.291.9.1114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methods to Increase the Percentage of Free Fetal DNA Recovered From the Maternal CirculationPMID 14996781Read ↗

Treatment of Maternal Blood Samples with Formaldehyde Does Not Alter the Proportion of Circulatory Fetal Nucleic Acids (DNA and mRNA) in Maternal PlasmaSemantic proximity Read ↗

A non-invasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study.Semantic proximity Read ↗

Hemolysis and Fetal Fraction in Cell-Free DNA Blood Collection Tubes for Noninvasive Prenatal TestingSemantic proximity Read ↗

Lack of Dramatic Enrichment of Fetal DNA in Maternal Plasma by Formaldehyde TreatmentSemantic proximity Read ↗

Cell-Free Fetal Nucleic Acid Testing: A Review of the Technology and Its ApplicationsSemantic proximity Read ↗

Stability of cell-free DNA from maternal plasma isolated following a single centrifugation stepSemantic proximity Read ↗

A new methodology to preserve the original proportion and integrity of cell‐free fetal DNA in maternal plasma during sample processing and storageSemantic proximity Read ↗

Implementing Prenatal Diagnosis Based on Cell-Free Fetal DNA: Accurate Identification of Factors Affecting Fetal DNA YieldSemantic proximity Read ↗

Cell-free fetal DNA and intact fetal cells in maternal blood circulation: implications for first and second trimester non-invasive prenatal diagnosisSemantic proximity Read ↗

Cell-free fetal DNA and RNA in maternal blood: implications for safer antenatal testingSemantic proximity Read ↗

Noninvasive Prenatal Diagnosis of Fetal Chromosomal Aneuploidies by Maternal Plasma Nucleic Acid AnalysisSemantic proximity Read ↗

Selection of the optimal manual method of cell free fetal DNA isolation from maternal plasmaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.