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Selection of the optimal manual method of cell free fetal DNA isolation from maternal plasma

8 Dec 2012

Abstract excerpt

BACKGROUND: The cell free fetal DNA (cffDNA) present in plasma of pregnant women represents an important alternative source of DNA for non-invasive prenatal diagnosis. Due to the low quantity and increased fragmentation of cffDNA, the choice of DNA extraction method is a crucial step for downstream analyses. METHODS: In our study, the three spin column-based kits for isolation of cffDNA [DNA Blood Mini Kit (DBM),...

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PMID: 23241606
DOI: 10.1515/cclm-2012-0418

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