Article
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
The Biochemical journal - 1 Jun 2004
Flanagan Jack U, Maréchal Jean-Didier, Ward Richard, Kemp Carol A, McLaughlin Lesley A, Sutcliffe Michael J, Roberts Gordon C K, Paine Mark J I, Wolf C Roland
Abstract excerpt
Although the residues that determine the preference of CYP2D6 (cytochrome P450 2D6) for compounds containing a basic nitrogen are well characterized, the contribution of other active site residues to substrate binding and orientation is less well understood. Our structural model of CYP2D6 identifies the aromatic residue Phe120 as a likely major feature of the active site. To examine the role of Phe120, mutants of...
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