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Article

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Archives of biochemistry and biophysics - 1 Jul 1996

Mackman R, Tschirret-Guth R A, Smith G, Hayhurst G P, Ellis S W, Lennard M S, Tucker G T, Wolf C R, Ortiz de Montellano P R

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) catalyzes the oxidation of substrates with a positively charged nitrogen atom 5-7 angstroms from the site of the oxidation. The active-site topology of CYP2D6 is examined here with phenyl-, 2-naphthyl-, and p-biphenyldiazene, which react with P450 enzymes to form sigma-bonded aryl-iron (Fe-Ar) complexes. Ferricyanide-mediated migration of the aryl group from the iron to the porphyrin...

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Identifiers

PMID: 8660692
DOI: 10.1006/abbi.1996.0291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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