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Article

Conserved requirement of Lim1 function for cell movements during gastrulation.

Developmental cell - 1 Jan 2003

Hukriede Neil A, Tsang Tania E, Habas Raymond, Khoo Poh-Lynn, Steiner Kirsten, Weeks Daniel L, Tam Patrick P L, Dawid Igor B

Abstract excerpt

To investigate Lim1 function during gastrulation, we used transcript depletion through DEED antisense oligonucleotides in Xenopus and cell transplantation in mice. Xenopus embryos depleted of Lim1 lack anterior head structures and fail to form a proper axis as a result of a failure of gastrulation movements, even though mesodermal cell identities are specified. Similar disruption of cell movements in the mesoderm...

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PMID: 12530965
DOI: 10.1016/s1534-5807(02)00398-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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