Article
Relief of catabolite repression in a cAMP-independent catabolite gene activator mutant of Escherichia coli.
Research in microbiology - 1 Mar 2004
Karimova Gouzel, Ladant Daniel, Ullmann Agnes
Abstract excerpt
We isolated and characterized a new catabolite gene activator mutant (crp*) of Escherichia coli that confers cAMP-independent expression and total relief of catabolite repression of beta-galactosidase and tryptophanase synthesis. The two mutations responsible for this phenotype change the amino acids at codon 72 from Glu to Ala and at codon 144 from Ala to Thr in the corresponding CAP* protein.
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