Article
Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease.
Diabetes - 1 Mar 2004
Susztak Katalin, Böttinger Erwin, Novetsky Akiva, Liang Dan, Zhu Yanqing, Ciccone Emilio, Wu Dona, Dunn Stephen, McCue Peter, Sharma Kumar
Abstract excerpt
To describe gene expression changes that characterize the development of diabetic nephropathy, we performed microarray and phenotype analysis on kidneys from db/db mice (a model of type 2 diabetes), streptozotocin-induced diabetic C57BL/6J mice (a model of type 1 diabetes), and nondiabetic controls. Statistical comparisons were implemented based on phenotypic outcome characteristics of the animals. We used...
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