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Aneuploidy detection in single cells using DNA array-based comparative genomic hybridization

16 Feb 2004

Abstract excerpt

The use of metaphase comparative genomic hybridization (CGH) to screen all human chromosomes for aneuploidy in preimplantation embryos is hindered by the time required to perform the analysis. We report in this paper a novel approach to manufacture a DNA microarray for CGH for the detection of aneuploidy in single cells. We spotted human chromosome-specific libraries on glass slides that were depleted of...

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Share to Chromosomal and Genetic Variations
Share to Genomic variations and chromosomal abnormalities
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PMID: 14985479
DOI: 10.1093/humrep/gah038

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