Article
Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.
Molecular human reproduction - 1 Dec 2008
Wells Dagan, Alfarawati Samer, Fragouli Elpida
Abstract excerpt
One of the most important factors influencing embryo viability is chromosome imbalance (aneuploidy). Embryos derived from aneuploid gametes have little potential for forming a viable pregnancy, but cannot be distinguished from normal embryos using standard morphological evaluation. For more than a decade, preimplantation genetic screening (PGS) has been used to assist in the identification of aneuploid embryos....
Topics
- Chromosome Aberrations
- Comparative Genomic Hybridization
- Embryo, Mammalian
- Female
- Genetic Testing
- Humans
- In Situ Hybridization, Fluorescence
- Microarray Analysis
- Polymorphism, Single Nucleotide
- Pregnancy