Detection of aneuploidy in single cells using comparative genomic hybridization

Abstract excerpt

The ability of comparative genomic hybridization (CGH) to detect aneuploidy following universal amplification of DNA from a single cell, or a small number of cells, was investigated with a view to preimplantation diagnosis following in vitro fertilization, and prenatal diagnosis using fetal erythroblasts obtained from maternal blood. The DNA obtained from lysed single cells was amplified using degenerate...

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• Share to Chromosomal and Genetic Variations
• Share to Genomic variations and chromosomal abnormalities
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