Article
Lymphocyte development requires S-nitrosoglutathione reductase.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2010
Yang Zhiyong, Wang Zhi-En, Doulias Paschalis-Thomas, Wei Wei, Ischiropoulos Harry, Locksley Richard M, Liu Limin
Abstract excerpt
NO is critical to immunity, but its role in the development of the immune system is unknown. In this study, we show that S-nitrosoglutathione reductase (GSNOR), a protein key to the control of protein S-nitrosylation, is important for the development of lymphocytes. Genetic deletion of GSNOR in mice results in significant decrease in both T and B lymphocytes in the periphery. In thymus, GSNOR deficiency causes...
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