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Article

Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an <i>ex vivo</i> model of articular chondrocyte transplantation

1 Feb 2004

Abstract excerpt

BACKGROUND: Genetically engineered chondrocytes could be used to enhance cartilage repair. Fibroblast growth factor 2 (FGF-2) is a mitogen for chondrocytes and may be a candidate for gene transfer approaches to stimulate chondrocyte proliferation. In the present study, we tested the hypothesis that human FGF-2 (hFGF-2) gene transfer into articular chondrocytes modulates cell proliferation in an ex vivo model of...

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PMID: 14978777
DOI: 10.1002/jgm.488

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