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Article

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2004

Hansson Anna, Hance Nicole, Dufour Eric, Rantanen Anja, Hultenby Kjell, Clayton David A, Wibom Rolf, Larsson Nils-Göran

Abstract excerpt

We performed global gene expression analyses in mouse hearts with progressive respiratory chain deficiency and found a metabolic switch at an early disease stage. The tissue-specific mitochondrial transcription factor A (Tfam) knockout mice of this study displayed a progressive heart phenotype with depletion of mtDNA and an accompanying severe decline of respiratory chain enzyme activities along with a decreased...

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Identifiers

PMID: 14978272
DOI: 10.1073/pnas.0308710100
PMCID: PMC365756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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