Article
Identification of novel virulence-associated genes via genome analysis of hypothetical genes.
Infection and immunity - 1 Mar 2004
Garbom Sara, Forsberg Ake, Wolf-Watz Hans, Kihlberg Britt-Marie
Abstract excerpt
The sequencing of bacterial genomes has opened new perspectives for identification of targets for treatment of infectious diseases. We have identified a set of novel virulence-associated genes (vag genes) by comparing the genome sequences of six human pathogens that are known to cause persistent or chronic infections in humans: Yersinia pestis, Neisseria gonorrhoeae, Helicobacter pylori, Borrelia burgdorferi,...
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