Article
Segregation analysis of Alzheimer pedigrees: rare Mendelian dominant mutation(s) explain a minority of early-onset cases. French Alzheimer Collaborative Group.
American journal of medical genetics - 16 Feb 1996
Martinez M, Campion D, Babron M C, Hannequin D, Agid Y, Bellis M, Brice A, Mallet J, Michon A, Thomas-Anterion C, Clerget-Darpoux F
Abstract excerpt
Segregation analysis of Alzheimer disease (AD) in 92 families ascertained through early-onset ( < or = age 60 years) AD (EOAD) probands has been carried out, allowing for a mixture in AD inheritance among probands. The goal was to quantify the proportion of probands that could be explained by autosomal inheritance of a rare disease allele "a" at a Mendelian dominant gene (MDG). Our data provide strong evidence...
Topics
- Age Factors
- Age of Onset
- Alzheimer Disease
- Female
- Genes, Dominant
- Humans
- Male
- Mathematical Computing
- Mutation
- Pedigree
- Risk Factors