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Article

Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis <scp>B</scp> virus infection

26 Jan 2015

Abstract excerpt

Hepatocyte clone size was measured in liver samples of 21 patients in various stages of chronic hepatitis B virus (HBV) infection and from 21 to 76 years of age. Hepatocyte clones containing unique virus-cell DNA junctions formed by the integration of HBV DNA were detected using inverse nested PCR. The maximum hepatocyte clone size tended to increase with age, although there was considerable patient-to-patient...

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PMID: 25619231
DOI: 10.1111/jvh.12380

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