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Article

Dual functions of single-stranded DNA-binding protein in helicase loading at the bacteriophage T4 DNA replication fork.

The Journal of biological chemistry - 30 Apr 2004

Ma Yujie, Wang Tongsheng, Villemain Jana L, Giedroc David P, Morrical Scott W

Abstract excerpt

Semi-conservative DNA synthesis reactions catalyzed by the bacteriophage T4 DNA polymerase holoenzyme are initiated by a strand displacement mechanism requiring gp32, the T4 single-stranded DNA (ssDNA)-binding protein, to sequester the displaced strand. After initiation, DNA helicase acquisition by the nascent replication fork leads to a dramatic increase in the rate and processivity of leading strand DNA...

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Identifiers

PMID: 14871889
DOI: 10.1074/jbc.M311738200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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