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Article

Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011

Zhang Huidong, Lee Seung-Joo, Zhu Bin, Tran Ngoc Q, Tabor Stanley, Richardson Charles C

Abstract excerpt

Interactions between gene 4 helicase and gene 5 DNA polymerase (gp5) are crucial for leading-strand DNA synthesis mediated by the replisome of bacteriophage T7. Interactions between the two proteins that assure high processivity are known but the interactions essential to initiate the leading-strand DNA synthesis remain unidentified. Replacement of solution-exposed basic residues (K587, K589, R590, and R591)...

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Source

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Identifiers

PMID: 21606333
DOI: 10.1073/pnas.1106678108
PMCID: PMC3111293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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