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Article

The role of the C-domain of bacteriophage T4 gene 32 protein in ssDNA binding and dsDNA helix-destabilization: Kinetic, single-molecule, and cross-linking studies.

PloS one - 1 Jan 2018

Pant Kiran, Anderson Brian, Perdana Hendrik, Malinowski Matthew A, Win Aye T, Pabst Christopher, Williams Mark C, Karpel Richard L

Abstract excerpt

The model single-stranded DNA binding protein of bacteriophage T4, gene 32 protein (gp32) has well-established roles in DNA replication, recombination, and repair. gp32 is a single-chain polypeptide consisting of three domains. Based on thermodynamics and kinetics measurements, we have proposed that gp32 can undergo a conformational change where the acidic C-terminal domain binds internally to or near the...

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Identifiers

PMID: 29634784
DOI: 10.1371/journal.pone.0194357
PMCID: PMC5892887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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