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Article

Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis.

Environmental health perspectives - 1 Nov 1992

Kadlubar F F, Butler M A, Kaderlik K R, Chou H C, Lang N P

Abstract excerpt

The metabolic pathways associated with carcinogenic aromatic amines in humans provide an excellent example of polymorphisms that appear to be relevant to human carcinogenesis. In this regard, the N-acetylation of arylamines and the O-acetylation of their N-hydroxy metabolites are catalyzed preferentially by a genetically polymorphic acetyltransferase, high activity of which has been correlated with decreased risk...

Topics

Acetylation
Acetyltransferases
Amines
Colon
Colorectal Neoplasms
Cytochrome P-450 Enzyme System
Glucuronosyltransferase
Humans
Liver
Peroxidases
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pilot Projects

Polymorphism, Genetic

Risk Factors

Sulfotransferases

Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 1486865
DOI: 10.1289/ehp.929869
PMCID: PMC1519630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1486865-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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