Article
Factors confounding genetic linkage between atopy and chromosome 11q.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 1992
Moffatt M F, Sharp P A, Faux J A, Young R P, Cookson W O, Hopkin J M
Abstract excerpt
The results of testing for linkage between atopy and the chromosome 11 marker D11S97 is shown for all the 723 subjects genotyped by us up to January 1992. Lod score estimations were confounded by the high population prevalence of atopy, maternal inheritance of atopy at the 11q locus, genetic heterogeneity, and excess of atopy in families not ascertained through a single proband. Affected sib-pair analysis shows...
Topics
- Alleles
- Chromosomes, Human, Pair 11
- Fathers
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Techniques
- Genetic Variation
- Genotype
- Humans
- Hypersensitivity