Article
T-cell receptor constant beta chain polymorphisms and susceptibility to type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association - 1 Dec 1992
Hibberd M L, Millward B A, Wong F S, Demaine A G
Abstract excerpt
Several groups have previously shown that the T-cell receptor (TCR) constant-beta (C beta) chain locus is associated with susceptibility to Type 1 diabetes, although other studies have failed to show this. We have extended these studies by investigating 125 individuals with Type 1 diabetes and failed to confirm the significantly increased frequency of the 10;9.2 kb TCR-C beta/Bgl-II genotype in our patient...
Topics
- Adolescent
- Adult
- Alleles
- DNA Probes
- Diabetes Mellitus, Type 1
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Polymorphism, Genetic