A T cell receptor beta chain polymorphism is associated with patients developing insulin-dependent diabetes after the age of 20 years.

doi:10.1111/j.1365-2249.1990.tb05486.x

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Article

A T cell receptor beta chain polymorphism is associated with patients developing insulin-dependent diabetes after the age of 20 years.

Clinical and experimental immunology - 1 Dec 1990

McMillan S A, Graham C A, Hart P J, Hadden D R, McNeill T A

Abstract excerpt

We have studied the BglII polymorphism near the T cell receptor beta chain constant region (TcR-C beta) gene, HLA-DR genotypes and certain autoimmune features in 102 patients with type I (insulin-dependent) diabetes. There was a significant decrease in the frequency of the 1:1 genotype (P = 0.008) and an increase in the 1:2 genotype (P = 0.03) of the BglII TcR polymorphism in the group of patients who developed...

Topics

Adolescent
Adult
Age Factors
Autoantibodies
Child
Child, Preschool
DNA Probes
Diabetes Mellitus, Type 1
Female
Genotype
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Male

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Receptors, Antigen, T-Cell

Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed Open full text

Identifiers

PMID: 1979939
DOI: 10.1111/j.1365-2249.1990.tb05486.x
PMCID: PMC1535501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979939-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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