Article
Isolation of a human melanoma adapted Newcastle disease virus mutant with highly selective replication patterns.
Cancer research - 15 Sept 1990
Ahlert T, Schirrmacher V
Abstract excerpt
The apathogenic Newcastle disease virus (NDV) strain Ulster has been used successfully as an adjuvant component for active specific immunotherapy of malignant mouse lymphoma, and in nude mice it was shown to be able to lead to retardation of the s.c. growth of xenotransplanted human melanoma cells. In order to improve in vivo effectiveness of virotherapy of human tumors without significantly increasing the risk...
Topics
- Animals
- Humans
- Melanoma
- Mice
- Mutation
- Neoplasm Metastasis
- Newcastle disease virus
- Peptide Hydrolases
- T-Lymphocytes
- Tumor Cells, Cultured
- Viral Fusion Proteins
- Virus Replication