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Article

Genetic Modification of Oncolytic Newcastle Disease Virus for Cancer Therapy

24 Mar 2016

Abstract excerpt

UNLABELLED: Clinical development of a mesogenic strain of Newcastle disease virus (NDV) as an oncolytic agent for cancer therapy has been hampered by its select agent status due to its pathogenicity in avian species. Using reverse genetics, we have generated a lead candidate oncolytic NDV based on the mesogenic NDV-73T strain that is no longer classified as a select agent for clinical development. This...

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PMID: 27009956
DOI: 10.1128/jvi.00136-16

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