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A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors

15 Jan 2004

Abstract excerpt

Whereas the major folate transporter, the reduced folate carrier (RFC), has a physiological pH optimum, transport activities for folates and antifolates have been detected with low pH optima. Because the interstitial pH in solid tumors is generally acidic, the mechanisms by which antifolates are transported at low pH could be an important determinant of drug activity under these conditions. The current study...

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PMID: 14760095
DOI: 10.1158/1078-0432.ccr-1066-03

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