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Article

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.

American journal of physiology. Cell physiology - 1 Jul 2009

Unal Ersin Selcuk, Zhao Rongbao, Goldman I David

Abstract excerpt

The proton-coupled folate transporter (PCFT) SLC46A1 mediates uphill folate transport into enterocytes in proximal small intestine coupled to the inwardly directed proton gradient. Hereditary folate malabsorption is due to loss-of-function mutations in the PCFT gene. This study addresses the functional role of conserved charged amino acid residues within PCFT transmembrane domains with a detailed analysis of the...

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Identifiers

PMID: 19403800
DOI: 10.1152/ajpcell.00096.2009
PMCID: PMC2711648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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