Article
The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate.
Nature genetics - 1 Mar 2004
Chae Teresa H, Kim Seonhee, Marz Karla E, Hanson Phyllis I, Walsh Christopher A
Abstract excerpt
The hyh (hydrocephalus with hop gait) mouse shows a markedly small cerebral cortex at birth and dies postnatally from progressive enlargement of the ventricular system. Here we show that the small hyh cortex reflects altered cell fate. Neural progenitor cells withdraw prematurely from the cell cycle, producing more early-born, deep-layer cerebral cortical neurons but depleting the cortical progenitor pool, such...
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