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Article

Association of tryptophan 2,3 dioxygenase gene polymorphism with autism.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Feb 2004

Nabi Rafiqun, Serajee Fatema J, Chugani Diane C, Zhong Hailang, Huq A H M Mahbubul

Abstract excerpt

Although elevation of blood and platelet serotonin has been documented in autism, genetic analyses of serotonin transporter gene have given conflicting results. Tryptophan 2,3 dioxygenase (TDO2) is the rate-limiting enzyme in the catabolism of tryptophan, the precursor of serotonin. A mutation that results in decreased activity of the TDO2 can decrease catabolism of tryptophan and increase the level of whole body...

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Source

Identifiers

PMID: 14755447
DOI: 10.1002/ajmg.b.20147

Genes

TDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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