Article
Opinion: more mouse models and more translation needed for ALS.
Molecular neurodegeneration - 4 May 2023
Fisher Elizabeth M C, Greensmith Linda, Malaspina Andrea, Fratta Pietro, Hanna Michael G, Schiavo Giampietro, Isaacs Adrian M, Orrell Richard W, Cunningham Thomas J, Arozena Abraham Acevedo
Abstract excerpt
Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic' of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes. Thus, there are more than 30 familial ALS subtypes, with different, often unknown, molecular pathologies leading to a complex constellation of clinical phenotypes. We have mouse models for many genetic forms of the...
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