Article
Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians.
Diabetes - 1 Feb 2004
Gu Harvest F, Abulaiti Adili, Ostenson Claes-Göran, Humphreys Keith, Wahlestedt Claes, Brookes Anthony J, Efendic Suad
Abstract excerpt
Adiponectin (APM1) is an adipocyte-derived peptide. The APM1 gene is located on chromosome 3q27 and linked to type 2 diabetes. In patients with type 2 diabetes, the adiponectin level in plasma is decreased in comparison to healthy subjects. To identify genetic defects of the APM1 gene that contribute to the development of type 2 diabetes, we genotyped 13 single nucleotide polymorphisms (SNPs) in 106 patients with...
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