Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

doi:10.2337/diabetes.51.2.536

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Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

Diabetes - 1 Feb 2002

Hara Kazuo, Boutin Philippe, Mori Yasumichi, Tobe Kazuyuki, Dina Christian, Yasuda Kazuki, Yamauchi Toshimasa, Otabe Shuichi, Okada Terumasa, Eto Kazuhiro, Kadowaki Hiroko, Hagura Ryoko, Akanuma Yasuo, Yazaki Yoshio, Nagai Ryozo, Taniyama Matsuo, Matsubara Koichi, Yoda Madoka, Nakano Yasuko, Tomita Motowo, Kimura Satoshi, Ito Chikako, Froguel Philippe, Kadowaki Takashi

Abstract excerpt

An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the adiponectin gene (APM1) is located. Herein, we present evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes (P =...

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PMID: 11812766
DOI: 10.2337/diabetes.51.2.536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.PMID 11812766Read ↗

Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects.Semantic proximity Read ↗

Associations between single-nucleotide polymorphisms of the adiponectin gene, serum adiponectin levels and increased risk of type 2 diabetes mellitus in Iranian obese individuals.Semantic proximity Read ↗

The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin.Semantic proximity Read ↗

The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.Semantic proximity Read ↗

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The -11377C > G adiponectin gene polymorphism alters the adiponectin concentration and the susceptibility to type 2 diabetes in Thais.Semantic proximity Read ↗

Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.Semantic proximity Read ↗

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Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans.Semantic proximity Read ↗

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