Article
Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality.
Biomedical and environmental sciences : BES - 1 Dec 2008
Yang Min, Qiu Chang-Chun, Chen Wei, Xu Ling-Ling, Yu Miao, Xiang Hong-Ding
Abstract excerpt
OBJECTIVE: To identify the genetic defects of the the adiponectin (APM1) gene that contribute to the development of type 2 diabetes (T2DM) and determine the functional single nucleotide polymorphisms (SNPs) in the APM1 gene associated with T2DM in Han nationality. METHODS: The APM1 gene 5'-UTR was screened by direct sequencing to identify common polymorphisms. Identified SNPs were genotyped in 585 nondiabetic...
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