Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk.

Journal of the American Society of Nephrology : JASN - 1 Feb 2004

Clark Patsy, Dziarmaga Alison, Eccles Michael, Goodyer Paul

Abstract excerpt

In renal-coloboma syndrome (RCS), null mutations of the PAX2 gene cause renal hypoplasia due to a congenital deficit of nephrons; affected individuals may develop renal insufficiency in childhood. During normal kidney development, PAX2, is expressed at high levels throughout the arborizing ureteric bud (UB); recent observations suggest that one of its key roles is to suppress apoptosis in this collecting duct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Chloromethyl Ketones
Share to Caspase Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coloboma

Share to Hearing Loss, Sensorineural

Share to Kidney

Share to Mice, Mutant Strains

Share to Nephrons

Share to PAX2 Transcription Factor

Source

Identifiers

PMID: 14747376
DOI: 10.1097/01.asn.0000111248.23454.19

Genes

PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk.PMID 14747376Read ↗

Ureteric Bud Apoptosis and Renal Hypoplasia in Transgenic PAX2-Bax Fetal Mice Mimics the Renal-Coloboma SyndromeSemantic proximity Read ↗

Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice.Semantic proximity Read ↗

Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice.Semantic proximity Read ↗

The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.Semantic proximity Read ↗

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.Semantic proximity Read ↗

Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.Semantic proximity Read ↗

Angiotensin II AT2 receptor regulates ureteric bud morphogenesis.Semantic proximity Read ↗

Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development.Semantic proximity Read ↗

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidneySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.