Article
Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jan 2004
Guibinga Ghiabe H, Hall Frederick L, Gordon Erlinda M, Ruoslahti Erkki, Friedmann Theodore
Abstract excerpt
The production of potentially targetable VSV-G-pseudotyped retrovirus vectors has been hampered by inadequate understanding of the structure-function relationships of the VSV-G protein. In these studies we demonstrate assembly and production of MLV-based and HIV-1-based vector particles using VSV-G proteins modified by the insertion of a peptide ligand into a site corresponding to amino acid position 24 of the...
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