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Article

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.

The Journal of biological chemistry - 9 Apr 2004

Lloyd Matthew D, Lipscomb Sarah J, Hewitson Kirsty S, Hensgens Charles M H, Baldwin Jack E, Schofield Christopher J

Abstract excerpt

Deacetoxycephalosporin/deacetylcephalosporin C synthase (DAOC/DACS) is an iron(II) and 2-oxoglutarate-dependent oxygenase involved in the biosynthesis of cephalosporin C in Cephalosporium acremonium. It catalyzes two oxidative reactions, oxidative ring-expansion of penicillin N to deacetoxycephalosporin C, and hydroxylation of the latter to give deacetylcephalosporin C. The enzyme is closely related to...

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Identifiers

PMID: 14734549
DOI: 10.1074/jbc.M313928200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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