Article
Polymorphism of interleukin-1 receptor antagonist gene and obesity.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2004
Um Jae-Young, Lee Kang-Min, Kim Hyung-Min
Abstract excerpt
BACKGROUND: Cytokines appear to be major regulators of adipose tissue metabolism. Interleukin-1 receptor antagonist (IL-1ra) serum concentrations are increased in human obesity, and are under strong genetic control. We tested the hypothesis that the IL-1ra gene might be a candidate for obesity. METHODS: We investigated the frequency of a penta-allelic 86-bp tandem repeat (VNTR) in the intron 2 of IL-1ra gene in...
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