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Article

Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas

11 Dec 2003

Abstract excerpt

Follicular lymphoma (FL) is characterized by the activation of BCL2 through t(14;18)(q32;q21). Additional acquired mutations are necessary to generate a fully malignant clonal proliferation. Many of these secondary genetic alterations are visible in the clonal karyotype; however, the sequence by which they arise and their influence on clinical behavior have not been determined. The ability to address these issues...

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PMID: 14732921
DOI: 10.1002/gcc.10314

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