Article
Cypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly.
Nature neuroscience - 1 Feb 2004
Akum Barbara F, Chen Maxine, Gunderson Samuel I, Riefler Gary M, Scerri-Hansen Monica M, Firestein Bonnie L
Abstract excerpt
Dendrite branching has an important role in normal brain function. Here we report that overexpression of cypin, a protein that has guanine deaminase activity and is expressed in developing processes in rat hippocampal neurons, results in increased dendrite branching in primary culture. Mutant cypin proteins that lack guanine deaminase activity act in a dominant-negative manner when expressed in primary neurons....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.