Article
The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N6-ethenoadenine as preferred substrates.
The Journal of biological chemistry - 2 Apr 2004
Aamodt Randi M, Falnes Pål Ø, Johansen Rune F, Seeberg Erling, Bjørås Magnar
Abstract excerpt
The AAG family of 3-methyladenine DNA glycosylases was initially thought to be limited to mammalian cells, but genome sequencing efforts have revealed the presence of homologous proteins in certain prokaryotic species as well. Here, we report the first molecular characterization of a functional prokaryotic AAG homologue, i.e. YxlJ, termed bAag, from Bacillus subtilis. The B. subtilis aag gene was expressed in...
Topics
- Adenine
- Alkylation
- Animals
- Bacillus subtilis
- Cloning, Molecular
- DNA Glycosylases
- DNA Methylation
- Deamination
- Escherichia coli
- Hypoxanthine
- Mammals
- Molecular Sequence Data
- Mutation
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