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Article

The role of p53-target genes in human cancer.

Critical reviews in oncology/hematology - 1 Jan 2000

Tokino T, Nakamura Y

Abstract excerpt

The tumor suppressor gene p53 is mutated in a large proportion of human cancers. In some cellular conditions like DNA damage, the p53 gene is induced and its gene product is posttranscriptionally activated. p53 works as a transcriptional activator and induces the expression of its downstream target genes. This review will explain why expression of the normal p53 gene leads to tumor growth suppression. The p53 has...

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Source

Identifiers

PMID: 10714958
DOI: 10.1016/s1040-8428(99)00051-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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