Postprandial lipemia in subjects with hypobetalipoproteinemia and a single intestinal allele for apoB-48.

Abstract excerpt

Hypobetalipoproteinemia in many kindreds is associated with truncated forms of apoB-100. Mutations of the apoB gene specifying more than 20 different carboxyl terminal truncations of apoB have been identified ranging in length from apoB-2 to apoB-89. Truncations longer than apoB-48 appear to be secreted only by liver, while truncations shorter than apoB-48 are secreted by liver as well as intestine. Thus,...

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